Microtuble binding

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Research Description

Microtubules (MTs) are one of the major components of the cellular cytoskeleton and function in many processes, such as intercellular transport and DNA segregation. MTs are highly dynamic polymers that assemble and disassemble from their two ends: the fast-growing plus end and the slow-growing minus end. CAMSAP proteins regulate microtubule minus-end stability and localization and thus organize noncentrosomal microtubule networks, which are essential for cell division, polarization and differentiation. Using a combination of structural approaches, we studied how the CAMSAP-CKK domain binds to microtubules.