Novel functional insight in protein complex, possible new target for antibiotics
Researchers at Utrecht University have gained new insights into the stucture and function of a protein complex that maintains the outer membrane of a bacteria. Shutting down this protein complex makes it impossible for the membrane to maintain itself, causing the bacteria to die. This protein could present a promising target for novel antibiotics.
Publication:
Formation of the β-barrel assembly machinery complex in lipid bilayers as seen by solid-state NMR
Cecilia Pinto, Deni Mance, Tessa Sinnige, Mark Daniëls, Markus Weingarth & Marc Baldus
Nature Communications 9, Article number: 4135 (2018), DOI: 10.1038/s41467-018-06466-w
